MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway | Zendy

Xiaoli Li | Zendy; Jiuchang Zhong | Zendy; Zhen Zeng | Zendy; Hongjiang Wang | Zendy; Jing Li | Zendy; Xiaoyan Liu | Zendy; Xinchun Yang | Zendy

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MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway

Author(s) -

Xiaoli Li,

Jiuchang Zhong,

Zhen Zeng,

Hongjiang Wang,

Jing Li,

Xiaoyan Liu,

Xinchun Yang

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-490

Subject(s) - medicine , pi3k/akt/mtor pathway , apoptosis , protein kinase b , microbiology and biotechnology , cancer research , signal transduction , biology , biochemistry

Cardiomyocyte apoptosis plays an important role in the development of heart failure, which leads to high mortality in patients with cardiovascular diseases. In this study, we are focused to identify the role of miRNA-181c in the regulating of myocardial tissue apoptosis in the doxorubicin (DOX) or hypoxia/reoxygenation (H/R) induced H9C2 cardiomyocyte injury.

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