MicroRNA-374 is a potential diagnostic biomarker for atherosclerosis and regulates the proliferation and migration of vascular smooth muscle cells | Zendy

Weihong Wang | Zendy; Fenghua Ma | Zendy; Hongyan Zhang | Zendy

Open Access

MicroRNA-374 is a potential diagnostic biomarker for atherosclerosis and regulates the proliferation and migration of vascular smooth muscle cells

Author(s) -

Weihong Wang,

Fenghua Ma,

Hongyan Zhang

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-444

Subject(s) - vascular smooth muscle , microrna , pathogenesis , medicine , biomarker , receiver operating characteristic , gene knockdown , cell growth , asymptomatic , cancer research , pathology , smooth muscle , apoptosis , biology , gene , genetics

The occurrence and development of atherosclerosis (AS) are closely related to the abnormality of vascular smooth muscle cells (VSMCs), and multiple microRNAs (miRNAs) have been reported to participate in the pathogenesis of AS. This study explored the expression and clinical value of miR-374 in the serum of AS patients, and analyzed its effect on the proliferation and migration of VSMCs.

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