Downregulation of long noncoding RNA SNHG6 rescued propofol-induced cytotoxicity in human induced pluripotent stem cell-derived cardiomyocytes | Zendy

Zhongguo Ren | Zendy; Rong Hu | Zendy

Open Access

Downregulation of long noncoding RNA SNHG6 rescued propofol-induced cytotoxicity in human induced pluripotent stem cell-derived cardiomyocytes

Author(s) -

Zhongguo Ren,

Rong Hu

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-443

Subject(s) - cytotoxicity , downregulation and upregulation , competing endogenous rna , induced pluripotent stem cell , microrna , in vitro , microbiology and biotechnology , pharmacology , long non coding rna , biology , gene , biochemistry , embryonic stem cell

Propofol (PPF) overdose is a rare but lethal condition, which may lead to severe cardiac failure. In this study, we established an in vitro PPF-induced cardiac cytotoxicity model, and investigate the functional role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6).

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