Hypermethylation of miR-181b in monocytes is associated with coronary artery disease and promotes M1 polarized phenotype via PIAS1-KLF4 axis | Zendy

Zhonghua Wang | Zendy; Chunlei Li | Zendy; Xinyong Sun | Zendy; Zhu-qin Li | Zendy; Jia Li | Zendy; Lanfeng Wang | Zendy; Yanming Sun | Zendy

Open Access

Hypermethylation of miR-181b in monocytes is associated with coronary artery disease and promotes M1 polarized phenotype via PIAS1-KLF4 axis

Author(s) -

Zhonghua Wang,

Chunlei Li,

Xinyong Sun,

Zhu-qin Li,

Jia Li,

Lanfeng Wang,

Yanming Sun

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-407

Subject(s) - microrna , cancer research , klf4 , dna methylation , medicine , transfection , epigenetics , macrophage polarization , methylation , sumo protein , gene knockdown , microbiology and biotechnology , phenotype , biology , gene expression , gene , transcription factor , genetics , sox2 , ubiquitin

Dysregulated microRNAs are involved in the macrophage polarization and atherosclerotic development. Apart from microRNAs, alteration in DNA methylation is considered as one of the most frequent epigenetic changes. The purpose of the research is to investigate the altered methylation status of miR-181b in the circulating monocytes from patients with coronary artery disease (CAD) and explore the underlying mechanisms.

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