Inhibition of ERK or Akt ameliorates intimal hyperplasia via up-regulation of Cx37 and down-regulation of Cx43 in balloon injury rat model | Zendy

Lemen Pan | Zendy; Haizhen Ni | Zendy; Wen-Xu Jin | Zendy; Xiang Yao Su | Zendy

Open Access

Inhibition of ERK or Akt ameliorates intimal hyperplasia via up-regulation of Cx37 and down-regulation of Cx43 in balloon injury rat model

Author(s) -

Lemen Pan,

Haizhen Ni,

Wen-Xu Jin,

Xiang Yao Su

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-345

Subject(s) - neointima , proliferating cell nuclear antigen , restenosis , mapk/erk pathway , protein kinase b , immunostaining , medicine , intimal hyperplasia , hyperplasia , western blot , andrology , pathology , phosphorylation , endocrinology , immunohistochemistry , chemistry , biology , microbiology and biotechnology , stent , biochemistry , smooth muscle , gene

Connexins (Cxs) are reported to participate in atherosclerosis associated intimal hyperplasia (IH), while their function involved in the balloon injury (BI) induced IH and restenosis is less reported.

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