Exogenous endothelial progenitor cells reached the deficient region of acute cerebral ischemia rats to improve functional recovery via Bcl-2 | Zendy

Yan Hong | Zendy; Qing Yu | Zendy; Zhaohong Kong | Zendy; Meiyao Wang | Zendy; Renwei Zhang | Zendy; Yan Li | Zendy; Yumin Liu | Zendy

Open Access

Exogenous endothelial progenitor cells reached the deficient region of acute cerebral ischemia rats to improve functional recovery via Bcl-2

Author(s) -

Yan Hong,

Qing Yu,

Zhaohong Kong,

Meiyao Wang,

Renwei Zhang,

Yan Li,

Yumin Liu

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-329

Subject(s) - medicine , angiogenesis , progenitor cell , cd31 , ischemia , endothelial progenitor cell , pathology , stem cell , middle cerebral artery , immunology , biology , genetics

As discovered in our previous study, autologous endothelial progenitor cells (EPCs) protect against acute focal ischemia rat via the promotion of angiogenesis. However, it is unknown whether the EPCs that reached the deficient region were transplanted ones or the products of other auto-conversion cells they had promoted. This study aimed to gather direct evidence for determining if exogenous transplanted EPCs directly participate in angiogenesis in ischemic areas and attempted to clarify the related mechanism.

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