Ephrin B2 mediates high glucose induced endothelial-to-mesenchymal transition in human aortic endothelial cells | Zendy

Yuan Cheng | Zendy; Lihua Ni | Zendy; Changjiang Zhang | Zendy; Hao Xia | Zendy; Xiaoyan Wu | Zendy

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Ephrin B2 mediates high glucose induced endothelial-to-mesenchymal transition in human aortic endothelial cells

Author(s) -

Yuan Cheng,

Lihua Ni,

Changjiang Zhang,

Hao Xia,

Xiaoyan Wu

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-299

Subject(s) - cd31 , focal adhesion , ephrin , western blot , mesenchymal stem cell , microbiology and biotechnology , endothelial stem cell , chemistry , medicine , confocal microscopy , signal transduction , immunology , biology , in vitro , immunohistochemistry , biochemistry , gene

Previous study revealed that high glucose (HG) induced endothelial cell (EC) damage via endothelial-to-mesenchymal transition (EndMT). Recent studies suggested the role of Ephrin B2 in mediate ECs damage. However, the underlying mechanism remains unclear. The aim of the present study was to investigate whether Ephrin B2 mediates HG-induced EndMT in human aortic ECs (HAECs) and to determine the possible downstream signaling effector.

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