Non-invasive investigation of myocardial energetics in cardiac disease using 31P magnetic resonance spectroscopy | Zendy

Mark A. Peterzan | Zendy; Andrew Lewis | Zendy; Stefan Neubauer | Zendy; Oliver J. Rider | Zendy

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Non-invasive investigation of myocardial energetics in cardiac disease using 31P magnetic resonance spectroscopy

Author(s) -

Mark A. Peterzan,

Andrew Lewis,

Stefan Neubauer,

Oliver J. Rider

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-275

Subject(s) - context (archaeology) , medicine , energy metabolism , metabolism , obligate , hibernating myocardium , high energy phosphate , inorganic phosphate , substrate (aquarium) , energy demand , disease , cardiology , phosphate , biochemistry , phosphocreatine , chemistry , biology , natural resource economics , myocardial infarction , paleontology , ecology , revascularization , economics

Cardiac metabolism and function are intrinsically linked. High-energy phosphates occupy a central and obligate position in cardiac metabolism, coupling oxygen and substrate fuel delivery to the myocardium with external work. This insight underlies the widespread clinical use of ischaemia testing. However, other deficits in high-energy phosphate metabolism (not secondary to supply-demand mismatch of oxygen and substrate fuels) may also be documented, and are of particular interest when found in the context of structural heart disease. This review introduces the scope of deficits in high-energy phosphate metabolism that may be observed in the myocardium, how to assess for them, and how they might be interpreted.

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