In vivo effects of nitrosyl hydrogen on cardiac function and sarcoplasmic reticulum calcium pump (SERCA2a) in rats with heart failure after myocardial infarction | Zendy

Yanqing Guo | Zendy; Jiyao Xu | Zendy; Yongzhi Deng | Zendy; Li Wu | Zendy; Jingping Wang | Zendy; Jian An | Zendy

Open Access

In vivo effects of nitrosyl hydrogen on cardiac function and sarcoplasmic reticulum calcium pump (SERCA2a) in rats with heart failure after myocardial infarction

Author(s) -

Yanqing Guo,

Jiyao Xu,

Yongzhi Deng,

Li Wu,

Jingping Wang,

Jian An

Publication year - 2020

Publication title -

cardiovascular diagnosis and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.83

H-Index - 22

eISSN - 2223-3660

pISSN - 2223-3652

DOI - 10.21037/cdt-20-201

Subject(s) - contractility , heart failure , cardiac function curve , medicine , serca , endoplasmic reticulum , myocardial infarction , endocrinology , western blot , calcium , preload , atpase , calcium pump , enzyme , chemistry , hemodynamics , biochemistry , gene

Abnormal Ca2+ circulation in cardiomyocytes is an important cause of decreased myocardial contractility in failing hearts. Nitroxyl hydrogen (HNO) can oxidize Ca 2+ cycle-related proteins, alter their biological functions, promote Ca 2+ recovery as well as release, and enhance myocardial contractility. In this study, we aim to observe the effect of nitrosyl hydrogen (HNO) on the cardiac function of rats with heart failure and elucidate the underlying mechanism.

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