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Center for Neurosciences, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA Correspondence to: Yilong Ma, PhD. Center for Neurosciences, Institute of Molecular Imaging, The Feinstein Institutes for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA. Email: yma@northwell.edu. Provenance and Peer Review: This article was commissioned by the Editorial Office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Wu Y, Jiang JH, Chen L, et al. Use of radiomic features and support vector machine to distinguish Parkinson’s disease cases from normal controls. Ann Transl Med 2019;7:773.

Radiomics and supervised machine learning in the diagnosis of parkinsonism with FDG PET: promises and challenges