Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide-stimulated macrophage by suppressing the activation of the JNK/c-Jun signaling pathway | Zendy

Xiu Yu | Zendy; Dandan Chen | Zendy; Lingwei Wang | Zendy; Jie Li | Zendy; Khalid M. Khan | Zendy; Haihui Chen | Zendy; Yutian Liang | Zendy; Huanmin Luo | Zendy; Chen Qiu | Zendy

Open Access

Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide-stimulated macrophage by suppressing the activation of the JNK/c-Jun signaling pathway

Author(s) -

Xiu Yu,

Dandan Chen,

Lingwei Wang,

Jie Li,

Khalid M. Khan,

Haihui Chen,

Yutian Liang,

Huanmin Luo,

Chen Qiu

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.04.22

Subject(s) - western blot , lipopolysaccharide , inflammation , nitric oxide synthase , nitric oxide , tumor necrosis factor alpha , cytokine , signal transduction , chemistry , innate immune system , proinflammatory cytokine , macrophage , immunology , biology , microbiology and biotechnology , pharmacology , immune system , biochemistry , organic chemistry , gene , in vitro

Collectively, our findings showed that wogonoside notably suppresses LPS-stimulated production of inflammatory factors by repressing the activation of the JNK/c-Jun signaling pathway in macrophages. This suggests that wogonoside could serve as a promising therapeutic agent for pulmonary diseases related to macrophage inflammation.

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