RPE epithelial-mesenchymal transition plays a critical role in the pathogenesis of proliferative vitreoretinopathy

Department of Ophthalmology, Henan Provincial People’s Hospital, Zhengzhou 450003, China; Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou 450003, China; Department of Ophthalmology, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China; People’s Hospital of Henan University, Zhengzhou 450003, China; Ophthalmology Optometry Center, Peking University People’s Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China; Departments of Pathology and Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA Correspondence to: Shikun He, MD. Departments of Pathology and Ophthalmology, Keck School of Medicine of the University of Southern California, 2011 Zonal Ave, Los Angeles, CA 90033, USA. Email: shikunhe@usc.edu; Mingwei Zhao, MD, PhD. Ophthalmology Optometry Center, Peking University People’s Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, #11 Xizhimen South Street, Beijing 100044, China. Email: dr_zhaomingwei@163.com. Provenance and Peer Review: This article was commissioned by the Editorial Office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Cui L, Yu Y, Jin X, et al. miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1. Ann Transl Med 2019;7:751.