Open AccessCell adhesion molecule 2 (CADM2) promotes brain metastasis by inducing epithelial-mesenchymal transition (EMT) in human non-small cell lung cancer
Author(s) -
Lu Dai,
Jian Zhao,
Jun Yin,
Wenfan Fu,
Gang Chen
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.03.85
Subject(s) - gene knockdown , vimentin , epithelial–mesenchymal transition , cancer research , brain metastasis , metastasis , lung cancer , biology , pathology , medicine , cancer , immunohistochemistry , cell culture , genetics
The results showed that CADM2 might promote brain metastasis by inducing epithelial-mesenchymal transition (EMT) in human NSCLC. We propose that CADM2 can be used as a novel molecular target for the prevention and treatment in NSCLC with brain metastasis patients.
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