Open AccessThe JAK2/STAT3 pathway is involved in dexmedetomidine-induced myocardial protection in rats undergoing cardiopulmonary bypass
Author(s) -
Sining Pan,
Yanhua Chen,
Xu Zhang,
Yubo Xie
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.03.67
Subject(s) - cardiopulmonary bypass , dexmedetomidine , medicine , apoptosis , stat3 , stat protein , blot , immunohistochemistry , anesthesia , interleukin , pharmacology , cytokine , chemistry , biochemistry , sedation , gene
Dexmedetomidine treatment reduced CPB-related myocardial injury by inhibiting inflammatory reactions and myocardial apoptosis, and can be a potential therapy in CPB-related surgery.
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