Open AccessEnhanced glutamine utilization mediated by SLC1A5 and GPT2 is an essential metabolic feature of colorectal signet ring cell carcinoma with therapeutic potential
Author(s) -
Renjie Wang,
Wenqiang Xiang,
Ye Xu,
Lingyu Han,
Qingguo Li,
Weixing Dai,
Guoxiang Cai
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.03.31
Subject(s) - glutamine , organoid , colorectal cancer , cancer research , biology , cancer , chemistry , biochemistry , medicine , microbiology and biotechnology , amino acid
This study highlights enhanced glutamine uptake and glutaminolysis as a metabolic feature of colorectal SRCC and a potential therapeutic target.
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