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Biochemistry Laboratory, Pontchaillou Hospital CHU Rennes, Rennes, France; Univ Rennes, CHU Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) UMR_S 1085, Rennes, France; Internal Medecine, CHU Rennes, Rennes, France; Hematology, Pontchaillou Hospital CHU Rennes, Rennes, France Correspondence to: Dr. Caroline Moreau. Laboratoire de Biochimie-Toxicologie, Hôpital Pontchaillou – CHU Rennes, 2, rue Henri Le Guilloux, 35033 Rennes, France. Email: Caroline.MOREAU@chu-rennes.fr. Provenance: This is an invited article commissioned by the Guest Section Editor Dr. Ying Zhao (Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China). Comment on: Sepiashvili L, Kohlhagen MC, Snyder MR, et al. Direct Detection of Monoclonal Free Light Chains in Serum by Use of Immunoenrichment-Coupled MALDI-TOF Mass Spectrometry. Clin Chem 2019;65:1015-22.

How to quantify monoclonal free light chains in plasma cell disorders: which mass spectrometry technology?