How to quantify monoclonal free light chains in plasma cell disorders: which mass spectrometry technology? | Zendy

Caroline Moreau | Zendy; Charles R. Lefèvre | Zendy; Olivier Decaux | Zendy

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How to quantify monoclonal free light chains in plasma cell disorders: which mass spectrometry technology?

Author(s) -

Caroline Moreau,

Charles R. Lefèvre,

Olivier Decaux

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.03.200

Subject(s) - mass spectrometry , immunoglobulin light chain , monoclonal , chemistry , plasma , plasma cell , monoclonal antibody , computational biology , chromatography , medicine , physics , biology , antibody , immunology , quantum mechanics

Biochemistry Laboratory, Pontchaillou Hospital CHU Rennes, Rennes, France; Univ Rennes, CHU Rennes, INSERM, EHESP, IRSET (Institut de Recherche en Santé, Environnement et Travail) UMR_S 1085, Rennes, France; Internal Medecine, CHU Rennes, Rennes, France; Hematology, Pontchaillou Hospital CHU Rennes, Rennes, France Correspondence to: Dr. Caroline Moreau. Laboratoire de Biochimie-Toxicologie, Hôpital Pontchaillou – CHU Rennes, 2, rue Henri Le Guilloux, 35033 Rennes, France. Email: Caroline.MOREAU@chu-rennes.fr. Provenance: This is an invited article commissioned by the Guest Section Editor Dr. Ying Zhao (Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China). Comment on: Sepiashvili L, Kohlhagen MC, Snyder MR, et al. Direct Detection of Monoclonal Free Light Chains in Serum by Use of Immunoenrichment-Coupled MALDI-TOF Mass Spectrometry. Clin Chem 2019;65:1015-22.

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