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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Correspondence to: Tommaso Mauri. Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy. Email: tommaso.mauri@unimi.it. Provenance: This is an invited article commissioned by the Editorial Office, Annals of Translational Medicine. Comment on: Liu K, Huang C, Xu M, et al. PEEP guided by electrical impedance tomography during one-lung ventilation in elderly patients undergoing thoracoscopic surgery. Ann Transl Med 2019;7:757.

Cardio-respiratory physiology during one-lung ventilation: complex interactions in need of advanced monitoring