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Charité University Medicine Berlin, Berlin, Germany; Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany Correspondence to: Prof. Dr. Matthias Ocker. Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany. Email: matthias.ocker@charite.de. Provenance: This is an invited article commissioned by the Guest Section Editor Dr. Rui Liao (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China). Comment on: Tang X, Shu Z, Zhang W, et al. Clinical significance of the immune cell landscape in hepatocellular carcinoma patients with different degrees of fibrosis. Ann Transl Med 2019;7:528.

Dissecting the immune cell landscape in hepatocellular carcinoma—are we understanding complexity?