Open AccessMicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice
Author(s) -
Na Zhao,
Guojian Wang,
Shuang Long,
Mengjia Hu,
Jining Gao,
Xinze Ran,
Junping Wang,
Yongping Su,
Tao Wang
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.03.161
Subject(s) - inflammation , wound healing , medicine , immunohistochemistry , antagomir , microrna , pathology , immunology , biology , biochemistry , gene
Our findings reveal that miR-34a deficiency augments skin wound inflammation response and leads to impaired wound healing, which suggest that targeted inhibition of miR-34a for tissue repair/regeneration should be with serious consideration.
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