Alterations of the tumor microenvironment in glioblastoma following radiation and temozolomide with or without bevacizumab | Zendy

Ryota Tamura | Zendy; Toshihide Tanaka | Zendy; Yukina Morimoto | Zendy; Yuki Kuranari | Zendy; Yohei Yamamoto | Zendy; Jun Takei | Zendy; Yuichi Murayama | Zendy; Kazunari Yoshida | Zendy; Hikaru Sasaki | Zendy

Open Access

Alterations of the tumor microenvironment in glioblastoma following radiation and temozolomide with or without bevacizumab

Author(s) -

Ryota Tamura,

Toshihide Tanaka,

Yukina Morimoto,

Yuki Kuranari,

Yohei Yamamoto,

Jun Takei,

Yuichi Murayama,

Kazunari Yoshida,

Hikaru Sasaki

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.03.11

Subject(s) - temozolomide , bevacizumab , tumor microenvironment , medicine , glioma , cancer research , cd8 , cd163 , immunohistochemistry , cytotoxic t cell , radiation therapy , vascular endothelial growth factor , cd34 , oncology , immune system , chemotherapy , immunology , biology , stem cell , vegf receptors , in vitro , biochemistry , genetics , tumor cells , gene , phenotype

This was the first study to show the alterations of TME following RT and TMZ therapy using paired pre- and post-treatment malignant glioma samples. Long-term treatment of RT and TMZ might worsen immunosuppressive TME in malignant gliomas.

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