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Efficacy of a three-day prolonged-course of multiple-dose versus a single-dose of tranexamic acid in total hip and knee arthroplasty
Author(s) -
Xiangdong Wu,
Mian Tian,
Yao He,
Yu Chen,
Yuzhang Tao,
Long Shao,
Changqi Luo,
Pengcheng Xiao,
Zhenglin Zhu,
Jiacheng Liu,
Wei Huang,
Guixing Qiu
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.99
Subject(s) - medicine , tranexamic acid , regimen , total hip arthroplasty , total knee arthroplasty , arthroplasty , hemoglobin , surgery , anesthesia , blood loss
A three-day prolonged-course of multiple-dose of TXA was consistently effective in reducing post-operative Hb drops, estimated TBL, inflammatory responses, and fibrinolytic responses, which could be recommended for clinical practice. However, these findings need to be confirmed by prospective studies.

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