Platelet microRNA-15b protects against high platelet reactivity in patients undergoing percutaneous coronary intervention through Bcl-2-mediated platelet apoptosis | Zendy

Jinghan Wang | Zendy; Yi Yao | Zendy; Jiahui Zhang | Zendy; Xiaofang Tang | Zendy; Xianmin Meng | Zendy; Miao Wang | Zendy; Lei Song | Zendy; Jinqing Yuan | Zendy

Open Access

Platelet microRNA-15b protects against high platelet reactivity in patients undergoing percutaneous coronary intervention through Bcl-2-mediated platelet apoptosis

Author(s) -

Jinghan Wang,

Yi Yao,

Jiahui Zhang,

Xiaofang Tang,

Xianmin Meng,

Miao Wang,

Lei Song,

Jinqing Yuan

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.02.88

Subject(s) - platelet , microrna , apoptosis , percutaneous coronary intervention , medicine , platelet activation , microarray , conventional pci , cancer research , microbiology and biotechnology , immunology , chemistry , biology , gene expression , myocardial infarction , biochemistry , gene

Through the promotion of platelet apoptosis, platelet miR-15b negatively regulates platelet reactivity in patients undergoing PCI. Platelet apoptosis may represent a novel antiplatelet target for overcoming HPR in PCI treatment.

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