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Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK; Department of Urology, Addenbrooke’s Hospital, Cambridge, UK; Wellcome Sanger Institute, Cambridge, UK Correspondence to: Thomas J. Mitchell. Addenbrooke’s Hospital, Hills Rd, Cambridge, UK. Email: tjm@sanger.ac.uk. Provenance and Peer Review: This article was commissioned by the Editorial Office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Zhang C, Li Z, Qi F, et al. Exploration of the relationships between tumor mutation burden with immune infiltrates in clear cell renal cell carcinoma. Ann Transl Med 2019;7:648.

The influence of tumour mutational burden on renal cancer immune infiltration and survival