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Single-cell transcriptomics reveals the alteration of peripheral blood mononuclear cells driven by sepsis
Author(s) -
Miaoyun Wen,
Gengxin Cai,
Jingkun Ye,
Xinqiang Liu,
Hongguang Ding,
Hongke Zeng
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.35
Subject(s) - peripheral blood mononuclear cell , sepsis , transcriptome , immune system , immunology , monocyte , cell , biology , gene , medicine , gene expression , genetics , in vitro
Although the study was preliminary, we revealed sepsis-specific alteration of PBMCs and associated pathways. These results give a panoramic picture of PBMCs in composition, genes profiles, and pathway signatures that are driven by sepsis, which offers a unique perspective to understand disease progression or treatment in clinical practice.

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