Blockade of β-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis | Zendy

Shipeng Dang | Zendy; ZhenYe Zhang | Zendy; Ku-lin Li | Zendy; Jie Zheng | Zendy; LingLing Qian | Zendy; Xiaoyu Liu | Zendy; Ying Wu | Zendy; Zhang Changying | Zendy; Xiaoxi Zhao | Zendy; Zhiming Yu | Zendy; Ruxing Wang | Zendy; Tingbo Jiang | Zendy

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Blockade of β-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis

Author(s) -

Shipeng Dang,

ZhenYe Zhang,

Ku-lin Li,

Jie Zheng,

LingLing Qian,

Xiaoyu Liu,

Ying Wu,

Zhang Changying,

Xiaoxi Zhao,

Zhiming Yu,

Ruxing Wang,

Tingbo Jiang

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.02.31

Subject(s) - inflammasome , cardiac fibrosis , fibrosis , medicine , stimulation , myocardial fibrosis , signal transduction , heart failure , pharmacology , chemistry , endocrinology , inflammation , microbiology and biotechnology , biology

The present study indicated that activation of inflammasome by β-adrenergic signaling promotes cardiac fibrosis. Therefore, modulation of inflammasome during HF might provide a novel strategy to treat this disease.

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