The application of proteomics in the diagnosis and treatment of bronchial asthma | Zendy

Peng Xu | Zendy; Lingwei Wang | Zendy; Dandan Chen | Zendy; Mengjie Feng | Zendy; Yongzhen Lu | Zendy; Rongchang Chen | Zendy; Chen Qiu | Zendy; Jie Li | Zendy

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The application of proteomics in the diagnosis and treatment of bronchial asthma

Author(s) -

Peng Xu,

Lingwei Wang,

Dandan Chen,

Mengjie Feng,

Yongzhen Lu,

Rongchang Chen,

Chen Qiu,

Jie Li

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.02.30

Subject(s) - asthma , mechanism (biology) , proteomics , chemokine , disease , pathological , identification (biology) , computational biology , medicine , bioinformatics , immunology , biology , inflammation , gene , pathology , genetics , philosophy , botany , epistemology

Bronchial asthma is a common chronic inflammatory disease of the airways. Although its pathogenic mechanism remains unknown, it is influenced by both genetic and environmental factors. The emergence and application of proteomic technologies can help to facilitate analysis of the changes in transcription factors, inflammatory mediators, chemokines, cytokines, and cell apoptosis-and proliferation-related proteins in the pathological processes of asthma. Proteomic technologies can unearth prospects and theoretical bases for improved understanding of the biological mechanism of asthma and effective identification of diagnostic and therapeutic targets.

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