Open AccessPalmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells
Author(s) -
Zhixia Dong,
Qian Zhuang,
Min Ning,
Shan Wu,
Lungen Lu,
Xinjian Wan
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.21
Subject(s) - inflammasome , palmitic acid , hepatic stellate cell , chemistry , tlr4 , medicine , endocrinology , pharmacology , signal transduction , microbiology and biotechnology , biochemistry , biology , inflammation , fatty acid
Palmitic acid stimulates NLRP3 inflammasome activation through the TLR4-NF-κB signal pathway in HSCs. NLRP3 inflammasome activation in HSCs exacerbates the development of NASH to liver fibrosis.
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