Open AccessInhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy
Author(s) -
Wenbing Jiang,
Wei Zhao,
Fanhao Ye,
Shiwei Huang,
Youyang Wu,
Hao Chen,
Rui Zhou,
FU Guosheng
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.172
Subject(s) - apoptosis , western blot , viability assay , microbiology and biotechnology , chemistry , diatrizoate meglumine , protein kinase c , programmed cell death , medicine , biology , kinase , biochemistry , gene
Our findings reveal that inhibiting PKCβ2 protects HK-2 cells against meglumine diatrizoate and AGEs-induced apoptosis and autophagy, which provide a novel therapeutic insight for CIN in diabetic patients.
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