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UOC Ematologia, UOS Fisiopatologia delle Anemie, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Milan, Italy Correspondence to: Paola Bianchi, BSc, PhD. UOC Ematologia, UOS Fisiopatologia delle Anemie, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Via Francesco Sforza, 35, 20122 Milan, Italy. Email: paola.bianchi@policlinico.mi.it. Provenance and Peer Review: This article was commissioned by the Editorial Office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Xue J, He Q, Xie X, et al. Clinical utility of targeted gene enrichment and sequencing technique in the diagnosis of adult hereditary spherocytosis. Ann Transl Med 2019;7:527.

How will next generation sequencing (NGS) improve the diagnosis of congenital hemolytic anemia?