Open AccessEpigenetic landscape analysis of lncRNAs in acute myeloid leukemia with DNMT3A mutations
Author(s) -
YuJun Dai,
Fang Hu,
Siyuan He,
Yueying Wang
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.143
Subject(s) - myeloid leukemia , epigenetics , myeloid , biology , computational biology , medicine , genetics , cancer research , bioinformatics , gene
Our study was the first to use R878H conditional knock-in mouse model to predict the specific lncRNAs regulated by the mutation in AML. Six candidate genes were found to be associated with DNMT3A mutation with poor prognosis. Our results provided a possible treatment strategy for this disease.
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