Open AccessDonor-derived hypouricemia in irrelevant recipients caused by kidney transplantation
Author(s) -
Lisha Teng,
Yanling Zhang,
Luxi Ye,
Junhao Lv,
Youying Mao,
Ronen Schneider,
Jianghua Chen,
Hong Jiang,
Jianyong Wu
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.140
Subject(s) - hypouricemia , kidney transplantation , medicine , transplantation , kidney , urology , kidney tubules , uric acid
Two novel mutations of SLC22A12 were identified. Preliminary functional analysis revealed a potential deleterious effect of these mutations in the grafts derived from the donor and sequencing analysis expand the molecular mechanisms of renal hypouricemia.
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