Open AccessAlcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance
Author(s) -
Bao Chen Yang,
Shang Ying Wu,
Po Sing Leung
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.129
Subject(s) - fgf21 , endocrinology , medicine , insulin resistance , islet , glucose homeostasis , insulin , ex vivo , glucose tolerance test , downregulation and upregulation , biology , impaired glucose tolerance , type 2 diabetes , diabetes mellitus , pancreatic islets , in vivo , fibroblast growth factor , receptor , biochemistry , microbiology and biotechnology , gene
Long-term ethanol consumption induces FGF21 resistance-mediated pancreatic β-cell dysfunction, and thus diabetes pathogenesis risk.
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