Open AccessAZD3463, an IGF-1R inhibitor, suppresses breast cancer metastasis to bone via modulation of the PI3K-Akt pathway
Author(s) -
Guangfu Hu,
Cheng Wang,
Guangxia Hu,
Ge Wu,
Chengjiao Zhang,
Wei Zhu,
Cong Chen,
Yutong Gu,
Hongwei Zhang,
Ziang Yang
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.110
Subject(s) - cancer research , pi3k/akt/mtor pathway , protein kinase b , apoptosis , tunel assay , cell growth , bone metastasis , metastasis , chemistry , cancer , medicine , biochemistry
These findings suggested that AZD3463 could serve as a promising therapeutic molecule for treating BM in breast cancer patients, particularly when applied in conjunction with ZA or other antitumor agents.
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