Open AccessInstability and excessive mechanical loading mediate subchondral bone changes to induce osteoarthritis
Author(s) -
Jianxi Zhu,
Yong Zhu,
Wenfeng Xiao,
Yihe Hu,
Yusheng Li
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.02.103
Subject(s) - osteoarthritis , subchondral bone , medicine , chemistry , articular cartilage , pathology , alternative medicine
Diversified mechanical loading properties lead to OA progression through different mechanisms of subchondral bone remodeling. Acute ACLT led to OA through bone density reduction, while the contralateral side developed OA gradually due to subchondral bone sclerosis.
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