Open AccessEGCG protects vascular endothelial cells from oxidative stress-induced damage by targeting the autophagy-dependent PI3K-AKT-mTOR pathway
Author(s) -
Jiao Meng,
Yuhua Chen,
Junzhe Wang,
Jun-Ling Qiu,
Cuicui Chang,
Fangfang Bi,
Xiaopeng Wu,
Wei Liu
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2020.01.92
Subject(s) - autophagy , pi3k/akt/mtor pathway , atg5 , protein kinase b , oxidative stress , apoptosis , microbiology and biotechnology , chemistry , viability assay , tunel assay , transfection , programmed cell death , biology , biochemistry , gene
These results suggest that EGCG induces autophagy by targeting the mTOR pathway, indicating that EGCG has the potential to prevent and treat oxidative stress-related cardiovascular diseases.
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