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Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA Correspondence to: Nicolas S. Piuzzi, MD. Cleveland Clinic, 9500 Euclid Ave/A41, Cleveland, OH 44195, USA. Email: piuzzin@ccf.org. Provenance and Peer Review: This article was commissioned by the Editorial Office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Gwam C, Ohanele C, Hamby J, et al. Human placental extract: a potential therapeutic in treating osteoarthritis. Ann Transl Med 2020. doi: 10.21037/atm.2019.10.20.

Human placental extract: the feasibility of translation from basic science into clinical practice