Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation | Zendy

Daixi Jiang | Zendy; Jianbin Zhang | Zendy; Meng-Ting Li | Zendy; ShuangZhe Lin | Zendy; Yu-Qin Wang | Zendy; Yuanwen Chen | Zendy; JianGao Fan | Zendy

Open Access

Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation

Author(s) -

Daixi Jiang,

Jianbin Zhang,

Meng-Ting Li,

ShuangZhe Lin,

Yu-Qin Wang,

Yuanwen Chen,

JianGao Fan

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2020.01.14

Subject(s) - nonalcoholic fatty liver disease , steatosis , endocrinology , medicine , inflammation , lipid metabolism , fatty liver , proinflammatory cytokine , prolyl endopeptidase , adipose tissue , oil red o , biology , biochemistry , enzyme , disease , adipogenesis

Loss of PREP lowers the severity of hepatic steatosis and inflammatory responses in a high-fat diet-induced nonalcoholic steatohepatitis model. PREP inhibition may protect against NAFLD.

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