Low expression of A-kinase anchor protein 5 predicts poor prognosis in non-mucin producing stomach adenocarcinoma based on TCGA data | Zendy

Zishao Zhong | Zendy; Zhenhao Ye | Zendy; Guihua He | Zendy; Wang Zhang | Zendy; Jing Wang | Zendy; Suiping Huang | Zendy

Open Access

Low expression of A-kinase anchor protein 5 predicts poor prognosis in non-mucin producing stomach adenocarcinoma based on TCGA data

Author(s) -

Zishao Zhong,

Zhenhao Ye,

Guihua He,

Wang Zhang,

Jing Wang,

Suiping Huang

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.12.98

Subject(s) - proportional hazards model , stage (stratigraphy) , medicine , adenocarcinoma , survival analysis , mucin , oncology , immunohistochemistry , cancer , gastroenterology , pathology , biology , paleontology

Low expression of AKAP5 may be a potential molecular marker for predicting poor prognosis of NMSA. Besides, cholesterol homeostasis, glycolysis, estrogen response, adipogenesis, notch signaling, and peroxisome may be the key pathways regulated by AKAP5 in NMSA. It also suggested that AKAP5 might potentially have biological functions in the development of stomach adenocarcinoma.

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