Open AccessThe evolving treatment paradigm for BRAF V600 mutant colorectal cancer
Author(s) -
Jeremy D. Kratz,
Dustin A. Deming
Publication year - 2019
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2019.12.61
Subject(s) - colorectal cancer , mutant , mutation , cancer research , cancer , v600e , gene , medicine , biology , computational biology , bioinformatics , genetics
Metastatic colorectal cancer (CRC) is now being better understood as a collection of diseases with each distinguished by distinct molecular profiles. BRAF mutant cancers are an important CRC subtype composing about 10% of metastatic CRCs. Of those with a mutation in the BRAF gene, 80% possess the V600E mutation (1).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom