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The C of gefitinib was significantly different between  and  genotypes, but not with the efficacy of gefitinib treatment.  rs2032582 and rs10256836 polymorphisms were correlated treatment outcome. Polymorphisms analysis of  could be a predictive biomarker for gefitinib treatment.

annals of translational medicine

The analysis of pharmacokinetic and pharmacogenomic impact on gefitinib efficacy in advanced non-small cell lung cancer patients: results from a prospective cohort study