Prenatal dexamethasone exposure exerts sex-specific effect on placental oxygen and nutrient transport ascribed to the differential expression of IGF2 | Zendy

Juanjuan Guo | Zendy; Man Fang | Zendy; Siying Zhuang | Zendy; Yuan Qiao | Zendy; Wen Huang | Zendy; Qing Gong | Zendy; Dan Xu | Zendy; Yuanzhen Zhang | Zendy; Hui Wang | Zendy

Open Access

Prenatal dexamethasone exposure exerts sex-specific effect on placental oxygen and nutrient transport ascribed to the differential expression of IGF2

Author(s) -

Juanjuan Guo,

Man Fang,

Siying Zhuang,

Yuan Qiao,

Wen Huang,

Qing Gong,

Dan Xu,

Yuanzhen Zhang,

Hui Wang

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.12.156

Subject(s) - endocrinology , glut3 , medicine , placenta , dexamethasone , glucose transporter , glut1 , fetus , glut4 , biology , chemistry , pregnancy , insulin , genetics

Our study shows prenatal dexamethasone exposure exerts sex-specific influence on the placental oxygen and nutrient transport. This might be ascribed to the differential expression of IGF2 after PDE. These findings provide evidence on the dexamethasone-induced toxicity to the placenta and fetal development.

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