Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression | Zendy

Wei He | Zendy; Kaiming Yuan | Zendy; Bin Ji | Zendy; Yuan Han | Zendy; Jun Li | Zendy

Open Access

Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression

Author(s) -

Wei He,

Kaiming Yuan,

Bin Ji,

Yuan Han,

Jun Li

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.12.147

Subject(s) - microglia , proinflammatory cytokine , curcumin , neuroinflammation , tlr4 , rage (emotion) , pharmacology , chemistry , hmgb1 , inflammation , tumor necrosis factor alpha , glycation , neurotoxicity , receptor , medicine , immunology , biochemistry , biology , toxicity , neuroscience

Curcumin effectively inhibits Aβ-induced neuroinammation in microglia, partly by suppressing the expression of HMGB1, TLR4, and RAGE.

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