Targeting the mitogen-activated protein kinase-mediated vascular smooth muscle cell remodeling by angiotensin II | Zendy

Masanori Yoshizumi | Zendy; Yoji Kyotani | Zendy; Jing Zhao | Zendy; Kiichi Nakahira | Zendy

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Targeting the mitogen-activated protein kinase-mediated vascular smooth muscle cell remodeling by angiotensin II

Author(s) -

Masanori Yoshizumi,

Yoji Kyotani,

Jing Zhao,

Kiichi Nakahira

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.12.145

Subject(s) - angiotensin ii , protein kinase a , mitogen activated protein kinase , microbiology and biotechnology , vascular smooth muscle , smooth muscle , kinase , cancer research , medicine , biology , receptor

Angiotensin II (Ang II) is a main effector peptide of the renin-angiotensin system that plays an important role in various cardiovascular diseases associated with vascular smooth muscle cell (VSMC) proliferation and migration, including hypertension, atherosclerosis and myocardial infarction (1). Ang II causes a rapid rise in blood pressure by stimulating Ang II type 1 receptor in arterial VSMC to contract. Ang II is also associated with the slow onset of hypertension by cardiac and vascular remodeling induced by cardiovascular cellular hypertrophy, proliferation and migration (2).

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