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Mammalian kidney has at least 26 different cell types (1). The collecting duct derives from the ureteric bud (UB) (2). Nephrogenesis is completed before birth in human beings and mice but continues until postnatal day 11–15 in rats (3). However, renal functional maturation lags behind anatomic maturation in all species. Tubule hypertrophy and hyperplasia and interstitial expansion contribute to the postnatal size increase of the kidney (4). Unlike other segment of nephrons, which contains single epithelial cell type, the collecting duct contains principal cells (PCs) and intercalated cells. PCs and ICs express distinct transporters to enable water and sodium homeostasis and acid-base homeostasis, respectively (5).

annals of translational medicine

Notch signaling is essential in collecting duct epithelial cell fate determination during development and maintenance of cell type homeostasis in adult