Study on the antibacterial activities of emodin derivatives against clinical drug-resistant bacterial strains and their interaction with proteins | Zendy

Chengjie Ji | Zendy; Guang Xin | Zendy; Feixia Duan | Zendy; Wen Huang | Zendy; Taichang Tan | Zendy

Open Access

Study on the antibacterial activities of emodin derivatives against clinical drug-resistant bacterial strains and their interaction with proteins

Author(s) -

Chengjie Ji,

Guang Xin,

Feixia Duan,

Wen Huang,

Taichang Tan

Publication year - 2020

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.12.100

Subject(s) - emodin , chemistry , circular dichroism , antibacterial activity , biochemistry , bovine serum albumin , tryptophan , biophysics , combinatorial chemistry , bacteria , amino acid , biology , genetics

These results suggest that the main responses for the substantial antibacterial activities of HEI2 are a disruption of the bacterial plasma membrane function and the interaction with biological functional proteins. Furthermore, the study of the interaction of drugs with BSA, which has a fluorescent group tryptophan residue similar to many bio-functional proteins, will be a simple and inexpensive scope-reducing method in screening new drugs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research