miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1 | Zendy

Lian Cui | Zendy; Yali Lyu | Zendy; Xiaoliang Jin | Zendy; Yueye Wang | Zendy; Xiang Li | Zendy; Juan Wang | Zendy; Jieping Zhang | Zendy; Zhongzhu Deng | Zendy; Nan Yang | Zendy; Zixuan Zheng | Zendy; Yizheng Guo | Zendy; Chao Wang | Zendy; Rui Mao | Zendy; Jingying Xu | Zendy; Furong Gao | Zendy; Caixia Jin | Zendy; Jingfa Zhang | Zendy; Haibin Tian | Zendy; GuoTong Xu | Zendy; Lixia Lü | Zendy

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miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1

Author(s) -

Lian Cui,

Yali Lyu,

Xiaoliang Jin,

Yueye Wang,

Xiang Li,

Juan Wang,

Jieping Zhang,

Zhongzhu Deng,

Nan Yang,

Zixuan Zheng,

Yizheng Guo,

Chao Wang,

Rui Mao,

Jingying Xu,

Furong Gao,

Caixia Jin,

Jingfa Zhang,

Haibin Tian,

GuoTong Xu,

Lixia Lü

Publication year - 2019

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.11.90

Subject(s) - epithelial–mesenchymal transition , retinal pigment epithelium , microbiology and biotechnology , inner nuclear layer , laser capture microdissection , ganglion cell layer , cell migration , biology , cell , chemistry , retinal , gene expression , downregulation and upregulation , gene , biochemistry , genetics

Our findings demonstrate for the first time that miR-194 suppresses RPE cell EMT by functionally targeting ZEB1. The clinical application of miR-194 in patients with PVR merits further investigation.

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