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It is estimated that in 2018 there were 1.8 million patients diagnosed with colorectal cancer (CRC) worldwide resulting in 862,000 deaths, which is an increase from 2012 by 33% and 24%, respectively (1). Surgical resection remains the standard of care for resectable, non-metastatic, CRC.

Prolonged follow-up of colorectal cancer patients after 5 years: to follow or not to follow, that is the question (and how)!