ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications | Zendy

Yue Zhang | Zendy; Huizhu Qian | Zendy; Jing Xu | Zendy; Wen Gao | Zendy

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ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications

Author(s) -

Yue Zhang,

Huizhu Qian,

Jing Xu,

Wen Gao

Publication year - 2019

Publication title -

annals of translational medicine

Language(s) - English

Resource type - Journals

eISSN - 2305-5847

pISSN - 2305-5839

DOI - 10.21037/atm.2019.11.06

Subject(s) - adar , rna editing , inosine , biology , rna , transcription (linguistics) , computational biology , carcinogenesis , microrna , genetics , adenosine , bioinformatics , cancer , gene , biochemistry , linguistics , philosophy

Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep. Here, we review current important ADAR-mediated editing events, related carcinogenic mechanisms and applications in clinical medicine. Further exploration in ADARs can provide a new direction for cancer treatment.

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