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Dear editor, we have read with great interest the basic research paper entitled ‘ The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice ’, published recently by Engle et al . in the Science journal (1). This paper underline that CA 19-9 is not only the most used and well-known tumor biomarker for pancreatic cancer (2), but an active player in the acute pancreatitis and pancreatic cancer pathogenesis, and a potential target for future therapies (1).

Glycosylation alterations in acute pancreatitis and pancreatic cancer: CA19-9 expression is involved in pathogenesis and maybe targeted by therapy