Open AccessPlatelet-derived microparticles promote phagocytosis of oxidized low-density lipoprotein by macrophages, potentially enhancing foam cell formation
Author(s) -
Can Feng,
Qi Chen,
Min Fan,
Jun Guo,
Yu Liu,
Tao Ji,
Jiaqi Zhu,
Xianxian Zhao
Publication year - 2019
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm.2019.08.06
Subject(s) - foam cell , phagocytosis , chemistry , flow cytometry , platelet , macrophage , lipoprotein , cell , microbiology and biotechnology , immunology , biochemistry , biology , cholesterol , in vitro
The microparticles from activated platelets can increase the phagocytosis of Ox-LDL and the production of inflammatory cytokines by macrophages, which is related to the development of AS.
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